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Substrate binding, catalytic activity and inhibition of Y-CYP51A comparatively to Tulahuen CYP51.
| CYP51 ortholog |
Substrate binding parameters | Turnover number (nmol substrate/nmol P450 /min) |
Inhibition at I/E/S molar ratio 1:1:100, one hour reaction (%) |
||||
|---|---|---|---|---|---|---|---|
| Kd, (µM) |
ΔA (% low-to- high spin transition) |
Binding efficiency (ΔA/Kd) |
VNI | VNT | VFV | ||
| Tulahuen | 0.8 | 36 | 45 | 5.6±0.3 | 100 | 100 | 100 |
| Y-CYP51A | 1.54 | 48 | 31 | 2.0±0.2 | 51±2 | 35±3 | 99±0.8 |
