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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Cancer Res. 2014 Sep 30;74(23):6968–6979. doi: 10.1158/0008-5472.CAN-13-3369

Figure 4. VE-821 reactivates replication foci activity and firing in cells treated with the Top1 inhibitors, CPT andLMP-400.

Figure 4

(A) Experimental protocol. (B to G) Confocal images of representative cell nuclei immediately after the IdU pulse (see panel A). (B) Untreated cells, (C) CPT alone, (D) LMP-400 alone, (E) VE-821 alone, (F) co-treatment with VE-821 and CPT, and (G) co-treatment with VE-821 and LMP-400.