Table 2.
Effect of Prenatal or Newborn Screening CF Diagnosis on Mean Z-scores, 2008–2012
| CF Diagnosis | 2008 (N=647) | 2009 (N=586) | 2010 (N=634) | 2011 (N=610) | 2012 (N=680) |
|---|---|---|---|---|---|
| Not Screened, N (%) | 535 (82.7) | 450 (76.7) | 491 (77.4) | 450 (73.8) | 470 (69.0) |
| Screened, N (%) | 112 (17.3) | 136 (23.4) | 143 (22.6) | 160 (26.2) | 210 (31.0) |
| HFA Z-score | |||||
| Not Screened, Mean (SD) | −0.53 (0.97) | −0.61 (1.08) | −0.43 (1.03) | −0.44 (1.05) | −0.44 (1.03) |
| Screened, Mean (SD) | −0.21 (0.95) | −0.26 (1.04) | −0.01 (1.08) | −0.12 (1.02) | −0.16 (1.03) |
| P-valuea | 0.002 | 0.001 | <0.001 | 0.001 | 0.001 |
| FEV1 Z-score | |||||
| Not Screened, Mean (SD) | −0.55 (1.61) | −0.46 (1.53) | −0.38 (1.41) | −0.52 (1.60) | −0.52 (1.46) |
| Screened, Mean (SD) | −0.34 (1.51) | −0.15 (1.56) | −0.22 (1.50) | −0.08 (1.62) | 0.01 (1.35) |
| P-value | 0.202 | 0.043 | 0.23 | 0.003 | <0.001 |
| FVC Z-score | |||||
| Not Screened, Mean (SD) | −0.15 (1.54) | −0.17 (1.54) | 0.00 (1.33) | −0.25 (1.54) | −0.16 (1.45) |
| Screened, Mean (SD) | 0.13 (1.38) | 0.13 (1.52) | 0.08 (1.52) | 0.23 (1.57) | 0.31 (1.29) |
| P-value | 0.073 | 0.048 | 0.52 | 0.001 | <0.001 |
| FEV1/FVC Z-score | |||||
| Not Screened, Mean (SD) | −0.68 (1.20) | −0.47 (1.21) | −0.65 (1.15) | −0.51 (1.20) | −0.61 (1.22) |
| Screened, Mean (SD) | −0.84 (1.14) | −0.49 (1.18) | −0.52 (1.11) | −0.56 (1.10) | −0.52 (1.07) |
| P-value | 0.19 | 0.89 | 0.23 | 0.65 | 0.39 |
| FEF25-75 Z-score | |||||
| Not Screened, Mean (SD) | −0.60 (1.37)b | −0.58 (1.40)c | −0.67 (1.34)d | ||
| Screened, Mean (SD) | −0.60 (1.24)e | −0.52 (1.39)f | −0.39 (1.27)g | ||
| P-value | 0.99 | 0.63 | 0.012 | ||
a
T-test of means;
b
N = 467;
c
N = 429;
d
N = 446;
e
N = 127;
f
N = 150;
g
N = 206