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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Trends Biotechnol. 2014 Oct 2;32(11):586–594. doi: 10.1016/j.tibtech.2014.09.003

Figure 3.

Figure 3

Microengineered devices for measurements of platelet adhesion and contraction. (A) Platelet aggregates on collagen spots of different sizes after perfusion with whole blood. A threshold collagen pattern size of 20 μm was necessary for platelet adhesion [63]. Adapted with permission from [63]. (B) Microfluidic thrombosis device to independently control transthrombus pressure and wall shear stress. Localized collagen plug surrounding posts defines platelet adhesion site. In addition, its permeability allows for control of transthrombus pressure [66]. Adapted with permission from [66]. (C) A microfluidic device with high shear stenosis region for inducing thrombus formation in whole blood [67]. Adapted with permission from [67]. (D) Micropost array for measurement of platelet contractile force (PCF). Platelets form microclots and exert contractile forces on the micropost force sensors after adding thrombin [80]. Adapted with permission from [80]. (E) AFM for measuring the PCF of single platelets. As a single platelet contracts, its length shortens and cause the AFM cantilever to deflect [83]. Adapted with permission from [83].