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. Author manuscript; available in PMC: 2014 Dec 3.
Published in final edited form as: Drug Alcohol Depend. 2014 Jul 11;144:42–46. doi: 10.1016/j.drugalcdep.2014.06.040

Table 1.

Mediation of VEN-XR on marijuana abstinence by week.

Week Model 1:
Correlation analysis of
VEN-XR and
withdrawal scores		 Model 2:
Estimated effect of
VEN-XR on marijuana
smoking		 Model 3:
Estimated effect of VEN-XR on marijuana
smoking controlling for standardized
withdrawal scores		 Mediation effect:
Amount of estimated
mediation of
withdrawal score on
marijuan smoking in
VEN-XR		 Mediation effect:
Proportion of the effect
of VEN-XR on
marijuana smoking
accounted for by
marijuana withdrawal
scores
Beta, p-value of effect
at at time t 		Estimated risk
difference for VEN-XR,
p-value of effect c		 Estimated risk
difference for VEN-XR,
p-value of effect c’		 Exponentiated beta,
p-value of effect b		 Difference in risk
differences = c’-c
(model 2 compared to
model 3)		 % Decrease in risk
differences = 1-(c’/c)
(model 2 compared to
model 3)
1 0.0201 N/A N/A N/A N/A N/A
(0.8895)
2 0.1548 N/A N/A N/A N/A N/A
(0.2835)
3 0.1147 N/A N/A N/A N/A N/A
(0.4315)
4 0.1265 N/A N/A N/A N/A N/A
(0.3930)
5 0.2795 N/A N/A N/A N/A N/A
(0.0642)
6 0.2956 N/A N/A N/A N/A N/A
(0.0527)
7 0.3199 0.2548 0.1123 7.2 239 0.1425 0.5593
(0.0404) (0.009) (0.034) (0.0013)
8 0.4146 0.3719 0.1984 3.8259 0.1735 0.4665
(0.0097) (0.003) (0.014) (0.0034)
9 0.4210 0.4013 0.2250 4.9567 0.1763 0.4393
(0.0107) (0.008) (0.028) (0.0017)
10 0.4972 0.2925 0.0275 26.0531 0.2650 0.9060
(0.0029) (0.034) (0.380) (0.0003)
11 0.6238 0.2912 0.0707 7.5427 0.2205 0.7572
(0.0002) (0.086) (0.504) (0.0007)
12 0.5412 0.5519 0.3907 5.4794 0.1612 0.2921
(0.00140) (0.002) (0.006) (0.0030)