Table 1.
Effect of Diet and Treatment on Brain Metabolites
| Metabolite* | ||||||
|---|---|---|---|---|---|---|
| Treatment Group |
Lactate |
N- acetylaspartate |
GABA Glutamate |
Aspartate | Taurine | |
| SD-UR | 40.8 ±2.1 | 57.0 ±6.5 | 16.6 ±2.2 | 75.6 ±2.2 | 18.1 ±1.9 | 57.9 ±3.9 |
| SD-R | 36.6 ±1.4 | 56.3 ±3.9 | 12.7 ±0.7 | 73.1 ±2.9 | 15.3 ±0.8 | 56.5 ±3.0 |
| SD-R[Glu] | 39.1 ±1.9 | 55.8 ±1.9 | 10.9 ±0.7 | 70.9 ±4.1 | 13.4 ±1.3 | 53.1 ±2.8 |
| SD-R[Glu][2DG] | 40.5 ±2.6 | 57.0 ±2.9 | 10.2 ±1.4 | 74.8 ±1.8 | 13.3 ±1.9 | 53.2 ±2.5 |
| SD-R[Glu][bOHB] | 34.4 ±4.0 | 57.2 ±2.7 | 11.9 ±0.7 | 72.9 ±2.0 | 15.0 ±0.2 | 57.2 ±2.2 |
Values are ratios of 1H NMR peaks standardized to 1H NMR phosphocreatine + creatine peaks, represented as mean ± SEM. n = 4–6 mice per group.