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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Mol Biochem Parasitol. 2014 Aug 29;196(2):90–99. doi: 10.1016/j.molbiopara.2014.08.005

Fig. 10.

Fig. 10

LmjPEM1 (A) and LmjPEM2 (B) inhibition by choline analogs. PEMT assay with yeast strains scpem1Δscpem2Δ+LmjPEM1+L (A) and scpem1Δscpem2Δ+U+LmjPEM2 (B) was carried out at least twice in duplicate as described in Materials and methods in the absence or presence of 10 or 100 µM of various compounds. An activity of 100% corresponds to approximately 100 pmol/mgxhr and standard deviations are depicted. 1, octadecyltrimethylammonium bromide; 2, hexadecyltrimethylammonium bromide; 3, choline; 4, phosphocholine; 5, miltefosine; 6, octadecylphosphocholine; 7, ethanolamine; 8, hydroxyethylhydrazine. (A), (B), open bars, no drug; grey bars, 10 µM of compound; black bars, 100 µM of drug.