Table 2.

Treatment cycle and embryology parameters by day 3 FSH and E2 groups

	Mean ± SD or N (%)
Treatment Cycle	Group 1A FSH <10 E2 <40 (n=291)	Group 1B FSH <10 E2 ≥40 (n=256)	Group 2A FSH 10–15 E2 <40 (n=35)	Group 2B FSH 10–15 E2 ≥40 (n=21)	P-value
CC-IUI Cycles
No. subjects initiating CC-IUI a	243 (83.5)	215 (84.0)	23 (65.7)	14 (66.7)	.02
FSH-IUI Cycles
No. subjects initiating FSH-IUI b	90 (30.9)	94 (36.7)	14 (40.0)	8 (38.1)	NS c
Total gonadotropin dose (IU) in FSH-IUI cycle	1264.6 ± 787.9	1195.9 ± 575.1	1905.2 ± 779.4	1923.7 ± 987.5	<.0001
Peak E2 (pg/mL) in FSH-IUI cycle	756.8 ± 507.0	772.2 ± 567.5	558.9 ± 269.3	511.2 ± 332.1	.04
IVF cycles
No. subjects initiating IVF	178 (61.2)	171 (66.8)	22 (62.9)	18 (85.7)	NS
Total gonadotropin dose (IU) in IVF cycle	2891.0 ± 1466.2	2761.1 ± 1459.8	4290.0 ± 1787.8	3974.6 ± 1923.4	<.0001
Peak E2 (pg/mL) in IVF cycle	1968 ± 1188.8	1953.5 ± 1333.0	1293.5 ± 751.7	1236.4 ± 984.4	<.0001
No. oocytes retrieved	11.6 ± 6.0	11.0 ± 6.8	7.2 ± 5.0	5.5 ± 2.8	<.0001
No. MII oocytes d	9.7 ± 5.4	9.1 ± 5.8	6.0 ± 4.8	5.0 ± 2.8	<.0001
ICSI	12 (6.9)	21 (13.0)	4 (19.1)	0 (0)	NS
No. 2PN zygotes e	7.4 ± 4.9	6.4 ± 4.4	4.2 ± 4.4	3.7 ± 2.3	<.0001
No. embryos transferred	2.6 ± 1.5	2.5 ± 1.5	2.2 ± 1.4	2.0 ± 0.9	NS
No. cycles with ≥1 good quality embryo transferred f	224 (63.6)	206 (63.2)	23 (46.9)	17 (56.7)	NS
Day of ETg   Day 3   Day 5	307 (94.5) 18 (5.5)	291 (97.4) 6 (2.0)	44 (100.0) 0 (0)	28 (100.0) 0 (0)	NS
Elective single embryo transfer	33 (10.1)	27 (9.0)	10 (22.7)	4 (14.3)	NS
Cycles with no supernumerary embryos available for cryopreservation	223 (64.1)	229 (70.5)	43 (87.8)	25 (86.2)	<.001

^aCC-IUI=intrauterine insemination following treatment with clomiphene citrate

^bFSH-IUI=intrauterine insemination following stimulation with exogenous gonadotropins

^cNot statistically significant

^dMII=metaphase II (mature) oocytes

^e2PN=two pronuclei observed after fertilization

^fGood quality embryo was defined as having ≥8 cells on day 3, with <20% fragmentation

^gET=embryo transfer