. Author manuscript; available in PMC: 2015 Sep 1.

Published in final edited form as: Microbes Infect. 2014 Aug 11;16(9):762–767. doi: 10.1016/j.micinf.2014.07.009

Table 1.

Assessment of effect of hLF on S. mutans induced proinflammatory cytokine and CRP release in the serum samples.

Mice group	Serum inflammatory mediators following treatments (pg/ml)
Mice group	IFN-γ	TNF-α	IL-1β	IL-6	IL-10	IL12p70	CRP
LFKO^−/−C	30.0±2.1	16.5±2.	115.0±1.4	27.5±2.1	47.5±11	21.0±1.4	0.5±0.09
LFKO^−/−C+hLF	36.0±1.4	22.5±0.7	18.0±0.08	2.0±2.8^*	49.5±4.9	26.0±1.4	0.9±0.00
LFKO^−/−I	813.0±29.3^#	42.5±2.4^#	17.5±0.0^#	96.0±4.9^#	46.0±2.1^#	19.0±1.4^#	1.8±0.04^#
LFKO^−/−I+hLF	81.0±11.6^¶^§	24.5±4.7^¶^§	20.0±1.7^¶^§	216.0±4.9^$^§	59.0±7.1^$^§	23.5±3.8^¶^§	1.0±0.04^¶^§

Serum samples were collected at 48 h post-infection with or without hLF prophylaxis. The inflammatory cytokines were quantified after S. mutans and or hLF i.v. injections from serum samples. Significance in the levels was analyzed in triplicate experiments using Student’s t test and ANOVA and post hoc Tukey’ HST test between the groups.

p<0.05 between LFKO^−/−C vs. LFKO^−/−C+hLF groups,

p<0.05 significant difference between LFKO^−/−C vs. LFKO^−/−I groups,

^¶

p<0.05 significant difference between LFKO^−/−I vs. LFKO^−/−I+hLF groups,

^§

p<0.05 significant difference between LFKO^−/−C+hLF vs. LFKO^−/−I+hLF groups,

p<0.05 significant difference between LFKO^−/−C vs. LFKO^−/−I+hLF groups.