Table 2.
Tissue | Assay | Immune responses in different vaccine groups | ||||
---|---|---|---|---|---|---|
| ||||||
ALVAC/Env (N=6) | RepAd/Env (N=4) | DNA&Env (N=4) | DNA (N=4) | |||
| ||||||
PBMC | Gag CM9 cellular responsesa | − | + | +++ | +++ | |
|
|
|||||
Vagina | 1 of 3 | N/A | +++ | +++ | ||
| ||||||
plasma | Humoral responsesb | bAbc | +++ | ++ | +++ | ++ |
Nabc | ++ | +++ | +++ | + | ||
ADCCc | + | +++ | ++ | + | ||
ADCPc | ++ | +++ | ++ | + | ||
|
|
|||||
mucosa | IgA | 3 of 6 | 2 of 4 | 3 of 4 | 1 of 4 | |
IgG | 5 of 6 | 4 of 4 | 4 of 4 | 3 of 4 |
data from this report (Figures 4A and 6D)
humoral immune response data are from Vargas-Inchaustegui et al (38)
reflects relative magnitude