Table 2.

Regions exhibiting effects of healthy aging on neural recruitment in both positive and negative events

Region of Interest	Hemisphere	BA	MNI Coordinates			p-value	k
			x	y	z
Increased activity as a function of healthy aging
Frontal Lobe
Premotor Cortex	L	6	−10	−10	60	0.000	101
	L	6	−26	−20	62	0.001	53
Dorsal Prefrontal Cortex	L	9	−30	20	38	0.000	288
	L	9	−24	42	42	0.001	26T
	R	8	22	28	46	0.000	94
Anterior Prefrontal Cortex	L	10	−34	36	14	0.000	21T
Ventromedial Prefrontal Cortex	L	10	0	58	4	0.000	296
Medial Prefrontal Cortex	L	10	−16	56	14	0.000	64
Precentral Gyrus	R	4	32	−20	52	0.000	88
Ventrolateral Premotor Cortex	R	44	60	12	8	0.001	86
	L	47	−30	30	−12	0.001	11T
Parietal Lobe
Inferior Parietal Lobe	L	40	−60	−34	36	0.000	25T
Precuneus	L	31	−8	−58	34	0.000	62
Postcentral Gyrus	R	2	60	−32	42	0.001	23T
Temporal Lobe
Superior Temporal Gyrus	L	39	−40	−60	32	0.000	96
Inferior Temporal Gyrus	L	20	−58	−26	−20	0.001	19T
Middle Temporal Gyrus	L	21	−60	−14	−18	0.001	16T
Limbic Lobe
Posterior Cingulate	L	31	−6	−26	42	0.000	965
Other
Insula	R	13	52	−22	26	0.000	67
	R	13	40	−30	16	0.002	16T
	L	13	−56	−34	18	0.001	12T
Decreased activity as a function of healthy aging
Temporal
Fusiform Gyrus	L	37	−34	−50	−16	0.000	86
Inferior Temporal Gyrus	L	19	−46	−56	−8	0.003	13T
	R	18	22	−68	−4	0.000	20T
Occipital
Lingual Gyrus	L	18	−20	−72	−6	0.000	103
Cuneus	R	18	6	−74	18	0.001	147
Limbic
Posterior Cingulate	L	23	−4	−30	22	0.000	190

Clusters significant at an uncorrected threshold of p<.005, k ≤ 10 voxels

Up to 3 local maxima that are at least 8mm apart reported for each cluster. BA= approximate Brodmann Area; L=Left, R=Right

^TIndicates a cluster size smaller than the designated cluster size of 29