(A) Chemical structure of ICI 118,551 (hereafter referred to as ICI), a selective β2AR antagonist. (B) Schematic representation of the treatment paradigm. 8-month-old female 3xTg-AD and NonTg mice were administered 1 mg/kg ICI or 0.9% NaCl (control) via daily i.p. injections for 6 weeks (3xTg-AD mice, n=9/drug group; NonTg mice, n=12/drug group). During the last two weeks of injections, mice were tested in MWM and object recognition tests. (C) Percent weight change throughout the treatment. No statistically significant changes in body weight were detected for any of the groups of mice. Data are presented as means ± SEM.