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Treatment groups, time points and sample sizes
| Time (PI) | Age (months) | Treatment groups (n) | ||
|---|---|---|---|---|
| P301SBE | PBS | WTBE | ||
| 1 day | 2 | 5 | 5 | – |
| 2 weeks | 2.5 | 5 | – | – |
| 1 month | 3 | 5 | 5 | – |
| 2 months | 4 | 5 | – | – |
| 2.5 months | 4.5 | 10a | 5 | 8 |
Mice were unilaterally infused with P301S brain extract (P301SBE), sterile phosphate-buffered saline (PBS) or wild-type brain extract (WTBE), and were aged to pre-defined time points
PI post-infusion
a5 mice used for biochemistry
