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. Author manuscript; available in PMC: 2015 Nov 12.
Published in final edited form as: Vaccine. 2014 Sep 17;32(48):6537–6543. doi: 10.1016/j.vaccine.2014.08.087

Fig. 1.

Fig. 1

Neutralizing and anti-NS1 antibodies. (a–c) Neutralizing antibody responses elicited after a single immunization with TDV-4 (a) or TDV-2 (b) vaccines or tetravalent TDV (c). Individual serum samples collected from each group (day 56 post-primary immunization) were tested for neutralizing activity. Sera from group A were tested for neutralizing activity against DENV-4, sera from group B were tested for neutralizing activity against DENV-2 and DENV-4, and those from group C for tetravalent neutralizing antibody responses. Data present mean of neutralizing antibody titers against each virus ± SE. (d) Titration of immune serum collected from animals vaccinated with TDV on day 56 post-immunization or day 28 post-DENV-4 challenges against DENV-2 and DENV-4 NS1 antigens coated on an ELISA plate. Data represent the mean ± SD of titrations of individual serum for each time point tested against the DENV-2 and DENV-4 NS1 antigens ± SD. Normal mouse serum was tested as negative control (green line).