Table 1a. Neonatal Outcomes in randomized controlled trials – Glyburide.
| Author Ref | Drug | LGA | Macrosomia | Hypoglycemia | NICU admission | Perinatal mortality |
|---|---|---|---|---|---|---|
| Langer et al.3 | Glyburide (n=201) |
12 | 7 | 9 | 6 | 0.5 |
| Insulin (n=203) |
13 | 4 | 6 | 7 | 0.5 | |
|
| ||||||
| Bertini et al.12 | Glyburide (n=24) |
25 | 16 | 33** | ND | 0 |
| Insulin (n=27) |
4 | 0 | 4** | ND | 0 | |
| Acarbose (n=19) |
11 | 0 | 5** | ND | 0 | |
|
| ||||||
| Moore et al.27 | Glyburide (n=74) |
ND | 5 | 0 | 1 | ND |
| Metformin (n=75) |
ND | 1 | 1 | 5 | ND | |
|
| ||||||
| Silva et al.40 | Glyburide (n=96) |
20 | ND | 14 | 7 | 1 |
| Metformin (n=104) |
9 | ND | 11 | 9 | 1 | |
Data is presented as %.
LGA: Large for gestational age; NICU: neonatal intensive care unit; ND: Not determined;
Large for gestational age was defined as birth weight > 90th percentile.
Hypoglycemia was defined as blood sugar < 40 mg/dL unless noted.
**
Significance was tested by Microsoft Excel ANOVA, with 95% significance rate.