Table 2a. Neonatal Outcomes in randomized controlled trials – Metformin.
| Author Ref | Drug | LGA | Macrosomia | Hypoglycemia | NICU admission | Perinatal mortality |
|---|---|---|---|---|---|---|
| Rowan et al.6 | Metformin (n=363) |
19 | ND | 3* | 19 | 0 |
| Insulin (n=370) |
19 | ND | 8* | 21 | 0.3 | |
|
| ||||||
| Spaulonci et al.24 | Metformin (n= 46) |
ND | 0 | 13** | ND | ND |
| Insulin (n= 46) |
ND | 7 | 22 | ND | ND | |
|
| ||||||
| Niromanesh et al.29 | Metformin (n= 80) |
18** | 4 | 4 | 6 | 0 |
| Insulin (n= 80) |
35 | 10 | 3 | 3 | 0 | |
|
| ||||||
| Moore et al.27 | Glyburide (n=74) |
ND | 5 | 0 | 1 | ND |
| Metformin (n=75) |
ND | 1 | 1 | 5 | ND | |
|
| ||||||
| Silva et al.40 | Glyburide (n=96) |
20 | ND | 14 | 7 | 1 |
| Metformin (n=104) |
9 | ND | 11 | 9 | 1 | |
Data is presented as %.
LGA: Large for gestational age; NICU: neonatal intensive care unit; ND: Not Determined;
Large for gestational age was defined as birth weight > 90th percentile.
Hypoglycemia was defined as blood sugar <40 mg/dL unless noted.
*
Blood glucose < 28.8 mg/dL
**
P<0.05 compared with insulin.