Table 2b. Maternal Outcomes in Randomized Controlled Trials - Metformin.
| Author Ref | Drug | Preeclampsia | PIH | Cesarean Delivery | Preterm Delivery | |
|---|---|---|---|---|---|---|
| Rowan et al.6 | Metformin (n=363) |
6 | 4* | 36 | 12 | |
| Insulin (n=370) |
7 | 6* | 38 | 8** | ||
|
| ||||||
| Spaulonci et al.24 | Metformin (n=46) |
22 | ND | 72 | 11 | |
| Insulin (n= 46) |
15 | ND | 65 | 11 | ||
|
| ||||||
| Niromanesh et al.29 | Metformin (n= 80) |
6 | 5 | 43 | 11 | |
| Insulin (n= 80) |
9 | 14 | 46 | 5 | ||
|
| ||||||
| Moore et al.27a | Glyburide (n=74) |
4 | ND | 3** | ND | |
| Metformin (n=75) |
3 | ND | 15 | ND | ||
|
| ||||||
| Silva et al.40 | Glyburide (n=96) |
ND | ND | 68 | 4 | |
| Metformin (n=104) |
ND | ND | 66 | 5 | ||
Data is presented as %.
PIH: Pregnancy-Induced Hypertension; ND: Not Determined; Preterm delivery defined as birth < 37 weeks;
*
PIH defined by Australasian Hypertension in Pregnancy Guidelines (Blood pressure • 140 mmHg systolic and/or 90 mmHg diastolic).41
**
P < 0.05 compared with metformin.
a
Percentage of non-elective cesarean delivery.