Table 3. Top 13 genes upregulated in hypoxic tumors compared with normoxic tumors.
| Gene Symbol | Gene ID | Normoxia mRNA levels | Hypoxia mRNA levels | Fold Change (vs Normoxia) | p-value |
|---|---|---|---|---|---|
| LCN2 | 16819 | 3.18 | 724.01 | 54.03 | <0.05 |
| 35.24 | 451.08 | ||||
| KCNJ8 | 16523 | 4.43 | 320.04 | 45.34 | <0.01 |
| 4.26 | 121.15 | ||||
| SERPINA1b | 20701 | 3.88 | 118.36 | 35.17 | <0.01 |
| 1.71 | 69.55 | ||||
| HP | 15439 | 5.15 | 323.27 | 33.53 | <0.01 |
| 4.10 | 73.52 | ||||
| C130026I21Rik | 620078 | 1.00 | 74.43 | 29.15 | <0.05 |
| 7.54 | 86.07 | ||||
| AQP4 | 11829 | 10.18 | 102.57 | 24.40 | <0.05 |
| 1.00 | 59.09 | ||||
| HBA-a1/HBA-a2 | 110257/15122 | 79.81 | 1258.91 | 23.42 | <0.05 |
| 166.63 | 5795.39 | ||||
| IGK-v28/IGKc/IGKj1/IGKv4-53/IGKv6-23/IGKv8-30 | 110759/16071/16114/384419/546213/637227 | 16.77 | 94.15 | 21.90 | <0.05 |
| 4.95 | 422.48 | ||||
| ESM1 | 71690 | 17.78 | 600.56 | 21.62 | <0.01 |
| 61.20 | 847.30 | ||||
| FLYWCH2 | 76917 | 2.24 | 107.14 | 21.12 | <0.01 |
| 6.47 | 60.37 | ||||
| D1BWG0212E | 52846 | 2.95 | 136.84 | 20.66 | <0.05 |
| 16.24 | 149.24 | ||||
| ClCA1 | 12722 | 1.37 | 56.29 | 20.36 | <0.05 |
| 5.99 | 60.62 | ||||
| ABCC9 | 20928 | 1.19 | 43.84 | 20.08 | <0.01 |
| 3.29 | 36.10 |
LCN2: lipocalin 2, KCNJ8: potassium inwardly-rectifying channel subfamily J member 8, SERPINA1b: serine (or cysteine) peptidase inhibitor clade A member 1B, HP: haptoglobin, C130026I21Rik: RIKEN cDNA C130026I21 gene, AQP4: aquaporin 4, HBA-a1/HBA-a2: hemoglobin α, adult chain 1/hemoglobin α, adult chain 2, IGK-v28/IGKc/IGKj1/IGKv4-53/IGKv6-23/IGKv8-30: immunoglobulin κ chain variable 28 (V28)/immunoglobulin κ constant/immunoglobulin κ joining 1/immunoglobulin κ variable 4-53/immunoglobulin κ variable 6-23/immunoglobulin κ chain variable 8-30, ESM1: endothelial cell-specific molecule 1, FLYWCH2: FLYWCH family member 2, D1BWG0212E: DNA segment Chr 1 Brigham & Women's Genetics 0212 expressed, ClCA1: chloride channel calcium activated 1, ABCC9: ATP-binding cassette sub-family C (CFTR/MRP) member 9. Fold-change represents the ratio of the means of the mRNA levels for hypoxic and normoxic tumors. P-values are estimated by volcano plot analysis combined with t-test.