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. 2014 Dec 3;15(12):527. doi: 10.1186/s13059-014-0527-7

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© Luo et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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ROC plots under various perturbation profiles. Statistical tests in the legend are listed from best to worst (in terms of AUC values) for each setting. Note the striking reordering of test performance across subfigures with slight changes in experimental conditions. Simulations in EDDA were done with (a) PDA =10%, (b) PDA = (50% UP, 25% DOWN), (c) PDA = (50% UP, 25% DOWN), FC = Log-normal (2, 1), (d) PDA = (50% UP, 25% DOWN), AP = HBR. Unless stated otherwise, common parameters include NR =3, EC =1,000, FC = Uniform(3, 7), ND =500 per entity, AP = BP, SM = Full, and SV =0.5.