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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Semin Cell Dev Biol. 2014 Sep 28;0:204–212. doi: 10.1016/j.semcdb.2014.09.022

Figure 4. Differential activation of pore and leak pathways by cytokine signaling. The relationship between tight junction proteins and the pore and leak pathways.

Figure 4

A. TNF increases leak pathway paracellular permeability via MLCK activation and occludin endocytosis. B. IL-13 increases pore pathway permeability by upregulating claudin-2 expression. See text for details.