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. 2013 Nov 19;74(3):314–320. doi: 10.1002/pros.22753

I.

Approved Agents for the Treatment of Castrate Resistant Prostate Cancer

Agent Target Year approved Reference
Estramustine Estrogen mimetic 1981 1
Mitoxantrone Type II topoisomerase 1996 2
Zoledronic acid Osteoclast inhibition (adjunctive) 2002 3
Docetaxel Microtubules 2004 4
Sipuleucel T Immunomodulation 2010 5
Cabazitaxel Microtubules 2010 6
Denosumab RANK ligand (adjunctive) 2010 7
Abiraterone Androgen synthesis 2011 8
Enzalutamide Androgen receptor 2012 9
Radium-223 Calcium mimetic 2013 10