I.

Approved Agents for the Treatment of Castrate Resistant Prostate Cancer

Agent	Target	Year approved	Reference
Estramustine	Estrogen mimetic	1981	1
Mitoxantrone	Type II topoisomerase	1996	2
Zoledronic acid	Osteoclast inhibition (adjunctive)	2002	3
Docetaxel	Microtubules	2004	4
Sipuleucel T	Immunomodulation	2010	5
Cabazitaxel	Microtubules	2010	6
Denosumab	RANK ligand (adjunctive)	2010	7
Abiraterone	Androgen synthesis	2011	8
Enzalutamide	Androgen receptor	2012	9
Radium-223	Calcium mimetic	2013	10