Distribution of the LEIsc scores. The x-axis represents LEIsc scores and the y-axis represents their frequencies. On the left, ESS values range from −0.0596 to −1.061, while on the right, the ESE values range from 0.0534 to 1.034. LEIsc, log of the enrichment index, scaled; ESS, exonic splicing silencers; ESE, exonic splicing enhancers.