Table 3.

Univariate and multivariate analysis of overall survival in all patients

Variable	Univariate analysis	Multivariate analysisa
	P-value	Hazard ratio	95% CI	P-value
Age	0.219
Gender	0.827
Extrahepatic spread	<0.001*	1.667	1.022–2.717	0.040*
Synchronous disease	0.143
Presence of pulmonary nodules	0.039*	1.215	0.775–1.908	0.395
Previous liver directed intervention	0.030*	1.591	0.990–2.556	0.055
CEA response	0.560
Number of treatments	0.004*	1.418	0.881–2.283	0.150

^*Statistically significant.

^aMultivariate hazard ratios calculated for the clinical variables that were found to be significant on univariate analysis.

CEA, carcinoembryonic antigen.