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. 2014 Sep 10;5(19):8924–8936. doi: 10.18632/oncotarget.2441

Figure 5. Xenografts tumor assay for EGCG affect on p53null and wildtype human lung caner cells.

Figure 5

50mg/kg of EGCG was given by IP injection to nude (immune deficient) mice with Xenograft tumor from A549 (p53wt) and H1299 (p53null) human lung cancer cell lines. The treatment continues every other day for up to 40 days (21 injections total). The growth of p53wt tumor A549 was not significantly impacted by the EGCG injections. (A) A549 without EGCG injection (dark brown line) and A549 with EGCG injection (light brown line); however, the growth of p53null tumor H1299 was significantly delayed by EGCG injections. Out of 12 tested tumors, 5 of them exhibited a complete reduction of tumor volume to not being able to be detected (green line) and 7 of them exhibited a regression of tumor volume in the first 12 days and a delayed growth of the tumor after that (light blue line) comparing to H1299 without EGCG injection (dark blue line) (B). The comparison of all the merged curves can be seen in (C). p-value was obtained from repeated measure growth curve analysis. For A549 p53wt control vs. EGCG, p-value=0.58; For H1299 p53null control vs EGCG (group 1), p-value=0.003; For H1299 p53null control vs. EGCG (group 2), p-value<0.001.