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. 2014 Aug 21;5(19):9092–9105. doi: 10.18632/oncotarget.2377

Figure 2. LGR5 promotes the growth of cervical cancer xenografts in vivo.

Figure 2

(A) A western blot assay was used to characterize the expression of LGR5 in LGR5-knockdown and -overexpressing HeLa cells. (B) The tumor growth curve of LGR5-knockdown HeLa cells injected into female nude mice is shown. (C) The tumor growth curve of LGR5-overexpressing HeLa cells injected into female nude mice is shown. (D) A western blot assay was used to characterize the expression of LGR5 in LGR5-knockdown or -overexpressing SiHa cells. (E) The tumor growth curve of LGR5-knockdown SiHa cells injected into female nude mice is shown. (F) The tumor growth curve of LGR5-overexpressing SiHa cells injected into female nude mice is shown. (G) At the end of the experiment, the tumor tissues were dissected, and the weights were measured. (H) Immunohistochemical staining for Ki67 in tumor tissues, scale bar, 10 μm. shLGR5: shRNA for LGR5; shCtr: shRNA for control; GFP: green fluorescent protein. Values are shown as the mean±SD. * p<0.05, ** p<0.01 vs. control using One-Way ANOVA.