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. 2014 Aug 21;5(19):9106–9117. doi: 10.18632/oncotarget.2379

Figure 4. MiR-339-5p inhibits the migration and invasion of colorectal cancer cells in a largely p53-dependent manner.

Figure 4

(A) MiR-339-5p inhibited the migration of colorectal cancer cells in a largely p53-dependent manner. HCT116 p53+/+ and p53−/− cells transfected with miR-339-5p mimic or miR-con were seeded into chambers for migration assays. Left panels: Representative images of migrated cells; Right panel: Quantifications of average number of migrated cells per field. (B) MiR-339-5p inhibited the invasion of colorectal cancer cells in a largely p53-dependent manner. HCT116 p53+/+ and p53−/− cells transfected with miR-339-5p mimic or miR-con were seeded into matrigel-coated chambers for invasion assays. Left panels: Representative images of invading cells; Right panel: Quantifications of average number of invading cells per field. (C, D) The miR-339-5p inhibitor promoted the migration (C) and invasion (D) of colorectal cancer cells in a largely p53-dependent manner. HCT116 p53+/+ and p53−/− cells transfected with miR-339-5p inhibitor or miR-con inhibitor were used for migration and invasion assays as described in A and B, respectively. Data are presented as mean ± SD (n=3). #: p<0.05; *: p<0.01; **: p<0.001; two-tailed Student t-tests.