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. 2014 Nov 1;5(19):9396–9409. doi: 10.18632/oncotarget.2414

Figure 1. Upregulation of helicases and nucelases that are highly mutated in breast or ovarian cancers by estrogen.

Figure 1

(A) screen architecture. The screen scored for genes that are upregulated by estrogen, part of the DNA damage response and highly mutated in estrogen-dependent cancers. (B) MCF7 cells were treated with E2 (25nM) or mock treated for 24h. Expression levels of indicated genes were detected by real-time PCR. Gene expression levels were normalized to GAPDH. Black bars represent control genes. Gray bars represent genes of interest.