Table 5.
Lysine methyltransferases
| Proposed symbol* | Synonyms and other symbols | Histone substrate specificity | Uni-ProtKB/Swiss-Prot assession number |
|---|---|---|---|
| KMT1A | SUV39H1, SUV39H | H3K9me2/3 | O43463 |
| KMT1B | SUV39H2, FLJ23414 | H3K9me2/3 | Q9H5I1 |
| KMT1C | G9a, EHMT2, C6orf30, BAT8, Em:AF134726.3, NG36/G9a | H3K9me1/2, H1K26me1/2 | Q96KQ7 |
| KMT1D | GLP, EHMT1, Eu-HMTase1, FLJ12879, KIAA1876, bA188C12.1 | H3K9me1/2 | Q9H9B1 |
| KMT1E | ESET, SETDB1, KG1T, KIAA0067, TDRD21 | H3K9me2/3 | Q15047 |
| KMT1F | SETDB2, CLL8, C13orf4, CLLD8 | H3K9me2/3 | Q96T68 |
| KMT2A | MLL1, TRX1, HRX, ALL-1, HTRX1, CXXC7, MLL1A, MLL | H3K4me1/2/3 | Q03164 |
| KMT2B | MLL2, KIAA0304, TRX2, HRX2, WBP7, MLL1B, MLL4 | H3K4me1/2/3 | Q9UMN6 |
| KMT2C | MLL3, KIAA1506, HALR | H3K4me1/2/3 | Q8NEZ4 |
| KMT2D | MLL4, TNRC21, MLL2, ALR, CAGL114 | H3K4me1/2/3 | O14686 |
| KMT2E | MLL5, HDCMC04P | H3K4me1/2/3 | Q8IZD2 |
| KMT2F | hSET1A, SETD1A, KIAA0339, Set1 | H3K4me1/2/3 | O15047 |
| KMT2G | hSET1B, SETD1B, KIAA1076, Set1B | H3K4me1/2/3 | Q9UPS6 |
| KMT2H | ASH1, ASH1L, huASH1, ASH1L1 | H3K4me1/2/3, H3K9me1/2/3, H4K20me1/2/3 | Q9NR48 |
| KMT3A | SET2, SETD2, HYPB, HIF-1, KIAA1732, FLJ23184 | H3K36me3 | Q9BYW2 |
| KMT3B | NSD1, STO, ARA267, FLJ22263 | H3K36me1/2, H4K20me1/2 | Q96L73 |
| KMT3C | SYMD2, HSKM-B, ZMYND14 | H3K36me1/2 | Q9NRG4 |
| KMT3D | SMYD1, BOP, ZMYND22 | Unknown | Q8NB12 |
| KMT3E | SMYD3, ZNFN3A1, ZMYND1 | H3K4me2/3 | Q9H7B4 |
| KMT4 | DOT1L, KIAA1814, DOT1 | H3K79me1/2/3 | Q8TEK3 |
| KMT5A | Pr-SET7, SETD8, SET07, SET8 | H4K20me1 | Q9NQR1 |
| KMT5B | SUV420H1, CGI-85 | H4K20me2/3 | Q4FZB7 |
| KMT5C | SUV420H2, MGC2705 | H4K20me2/3 | Q86Y97 |
| KMT6A | EZH2, EZH1, ENX-1, KMT6 | H3K27me1/2/3, H1K26me2/3 | Q15910 |
| KMT6B | EZH1, KIAA0388 | H3K27me1/2/3 | Q92800 |
| KMT7 | SET7/9, KIAA1717, SET7, Set9 | H3K4me2 | Q8WTS6 |
| KMT8 | PRDM2, RIZ1, RIZ, RIZ2, MTB-ZF, HUMHOXY1 | H3K9me1/2/3 | Q13029 |
*
Proposed symbols are those suggested by Allis et al. (2007). A list of the proposed lysine methyltransferase names and symbols that have been approved by the HUGO Gene Nomenclature Committee (HGNC) can be found at http://www.genenames.org/genefamilies/kdm-kat-kmt#KMT.