Table 5.
The system- and drug-specific parameter values from the extended drug-independent model used to predict effects on the CVS
| Parameter | Value | RSE | LLCI | ULCI |
|---|---|---|---|---|
| System-specific parameters | ||||
| BSL_HR_SHR (beats min-1) | 310 | 1.12 | 303 | 317 |
| BSL_MAP_SHR (mmHg) | 155 | 0.684 | 153 | 157 |
| BSL_CO_SHR (mL min-1) | 69.0 | 4.17 | 63.4 | 74.6 |
| BSL_HR _WKY(beats min-1) | 323 | 1.61 | 313 | 333 |
| BSL_MAP_WKY (mmHg) | 102 | 0.884 | 100 | 104 |
| BSL_CO_WKY (mL per min) | 129 | 1.47 | 125 | 133 |
| kout_HR (h−1) | 11.6 | 19.1 | 7.27 | 15.9 |
| kout_SV (h−1) | 0.126 | 30.7 | 0.0501 | 0.202 |
| kout_TPR (h−1) | 3.58 | 29.1 | 1.54 | 5.62 |
| FB0 (mmHg−1) | 0.00290 | 5.93 | 0.00256 | 0.00324 |
| FB0_MAP | −1.98 | 10.6 | −2.39 | −1.57 |
| HR_SV | 0.312 | 15.6 | 0.216 | 0.408 |
| kHD (h−1) | 4.70 | 8.19 | 3.95 | 5.45 |
| PHR | 0.632 | 9.67 | 0.512 | 0.752 |
| PTPR | 0.331 | 12.9 | 0.247 | 0.415 |
| horHR (h) | 8.73 | 3.10 | 8.20 | 9.26 |
| ampHR | 0.0918 | 5.15 | 0.0825 | 0.101 |
| horTPR (h) | 19.3 | 1.92 | 18.6 | 20.0 |
| ampHTPRR | Fixed to ampHR | |||
| Drug-specific parameters | ||||
| Amiloride: Emax model with Emax fixed to 1 | ||||
| EC50 (ng mL−1) | 245 | 25.1 | 125 365 | |
| Amlodipine: Emax model with Emax fixed to 1 | ||||
| EC50 (ng mL−1) | 82.8 | 4.99 | 74.7 | 90.9 |
| Atropine: linear model | ||||
| SL (ng mL−1)−1 | 0.00149 | 32.3 | 0.000547 | 0.00243 |
| Ka (h−1) | 1.17 | 59.9 | –0.204 | 2.54 |
| Enalapril: Emax model with Emax fixed to 1 | ||||
| EC50 (ng mL−1) | 1200 | 4.03 | 1110 | 1290 |
| ke0 (h−1) | 0.163 | 5.07 | 0.147 | 0.179 |
| Fasudil: Emax model with Emax fixed to 1 | ||||
| EC50 (ng mL−1) | 0.172 | 18.4 | 0.110 | 0.234 |
| HCTZ: Emax model with Emax fixed to 1 | ||||
| EC50 (ng mL−1) | 28 900 | 7.65 | 24 600 | 33 200 |
| Prazosin: power model | ||||
| SL (ng mL−1)−1 | 0.328 | 5.58 | 0.292 | 0.364 |
| POW | 0.0910 | 6.05 | 0.0802 | 0.102 |
| Interindividual variability | ||||
| BSL_HR (CV%) | 6.1 | 4.36 | 7.47 | |
| BSL_MAP (CV%) | 3.7 | 2.67 | 4.49 | |
| BSL_CO (CV%) | 22.7 | 18.09 | 26.57 | |
| Residual variability | ||||
| Prop. Res.ErrorHR (CV%) | 7.8 | 7.26 | 8.22 | |
| Prop. Res.ErrorMAP (CV%) | 6.0 | 5.44 | 6.57 | |
| Prop. Res.ErrorCO (CV%) | 6.9 | 5.72 | 7.83 | |
CV, coefficient of variation; LLCI, lower limit of 95% confidence interval; RSE, relative standard error of parameter estimate; ULCI, upper limit of 95% confidence interval.