Table 2.
Curve-fitting parameters for [125I]-CCL3 competition binding assays
| AZD4818 | BX471 | CCX354 | CP481715 | MLN-3897 | PS899877 | |
|---|---|---|---|---|---|---|
| pIC50 for HEK_CCR1/Gqi5 membranes | 8.629 ± 0.201 n = 2 | 7.74 ± 0.425 n = 3 | 8.88 ± 0.198 n = 1 | 7.971 ± 0.205 n = 3 | 9.933 ± 0.2217 n = 1 | 6.985 ± 0.2818 n = 1 |
| pIC50 for RPMI 8226 membranes | 6.797 ± 0.3827 n = 3 | 7.518 ± 0.3415 n = 4 | 6.507 ± 0.1991 n = 1 | 7.162 ± 0.2005 n = 6 | 8.839 ± 0.5723 n = 4 | 6.948 ± 0.232 n = 3 |
The table summarizes the pIC50 values of the six CCR1 antagonists analysed using membranes prepared from either HEK_hCCR1 cells or the MM cell line RPMI 8226.