Table 3.
Heart rate, blood pressure and forearm haemodynamics during infusion of acetylcholine and sodium nitroprusside
| Baseline |
Ach |
Baseline |
SNP |
|||||
|---|---|---|---|---|---|---|---|---|
| Young | Older | Young | Older | Young | Older | Young | Older | |
| Control | ||||||||
| HR (beats min−1) | 52 ± 3 | 59 ± 3 | 52 ± 3 | 60 ± 3 | 52 ± 3 | 61 ± 3 | 64 ± 4 | 66 ± 4 |
| MAP (mmHg) | 86.4 ± 3.0 | 94.0 ± 2.3* | 84.7 ± 3.2 | 93.6 ± 2.6* | 86.9 ± 3.4 | 94.2 ± 4.2* | 75.6 ± 2.3 | 81.8 ± 3.2 |
| FBF (ml min−1) | 30.9 ± 4.4 | 39.1 ± 4.2 | 258.8 ± 71.0 | 119.0 ± 20.1* | 30.1 ± 4.2 | 33.9 ± 3.6 | 200.1 ± 28.6 | 167.0 ± 21.6 |
| FVC (ml min−1 100 mmHg−1) | 35.8 ± 5.0 | 41.2 ± 4.2 | 309.9 ± 86.4 | 125.9 ± 20.4* | 34.7 ± 4.7 | 36.4 ± 3.4 | 263.2 ± 36.5 | 205.8 ± 27.5 |
| α + β-Adrenoreceptor blockade | ||||||||
| HR (beats min−1) | 52 ± 3 | 60 ± 3 | 55 ± 3 | 64 ± 3 | 52 ± 2 | 60 ± 3 | 61 ± 3 | 68 ± 3 |
| MAP (mmHg) | 89.5 ± 3.8 | 98.9 ± 2.7* | 87.6 ± 2.8 | 99.7 ± 3.1* | 92.1 ± 3.1 | 99.1 ± 3.4* | 78.1 ± 2.1 | 86.2 ± 2.8* |
| FBF (ml min−1) | 93.1 ± 17.5 | 75.2 ± 7.5 | 405.5 ± 60.5 | 252.7 ± 29.4* | 82.6 ± 7.9 | 74.0 ± 7.1 | 346.0 ± 41.3 | 279.8 ± 30.2 |
| FVC (ml min−1 100 mmHg−1) | 102.0 ± 16.5 | 75.7 ± 7.5 | 457.7 ± 68.3 | 259.7 ± 34.4* | 89.3 ± 7.8 | 74.4 ± 6.4 | 439.6 ± 50.2 | 324.0 ± 34.5* |
Values are mean ± SEM. *P < 0.05 vs. Young. Young: n = 8, Older: n = 11.