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. 2014 Sep 9;15(11):1175–1183. doi: 10.15252/embr.201439195

Figure 2. HDAC4 regulates the expression of Pax7 and associated genes in SCs.

Figure 2

A mRNA expression of genes in SCs. Activated SCs isolated from 15-week-old female mice were cultured for 3 days in growth medium (GM). Medium was changed at 2 days after plating. Columns, mean; bars, SEM. n = 5 for each group. **P < 0.01, ***P < 0.001 versus control KO+CTX (unpaired Student’s t-test).

B Protein expression of HDAC4, Pax7, and MyoG in SCs. Activated SCs isolated from muscles in 13-week-old female (Exp. no. 1) or 10-week-old male (Exp. no. 2) mice were cultured for 2 days in GM.

C, D mRNA expression of potential Pax7-target genes and Pax3 in damaged muscle. cDNAs used in Fig 1G were used. Columns, mean; bars, SEM. n = 4 for each group. **P < 0.01, ***P < 0.001 (unpaired Student’s t-test).