Table 2.
Interferon-γ (IFN-γ) genetic associations with disease
| Variation | Association | Ethnicity | References |
|---|---|---|---|
| rs2430561 (+874A/T) | Paediatric tuberculosis, particularly in females | Han Chinese | 21 |
| rs2069718 (+3234C/T) | |||
| rs2069705/rs2430561/rs2069718 haplotype | |||
| rs3138557 (CA repeat) | Ossification of the posterior longitudinal ligament | Korean | 22 |
| rs2430561 (+874T/A) | Increased fatigue during the acute sickness response | Caucasian | 23 |
| rs2430561 (+874T/A) | Paroxysmal nocturnal haemoglobinuria | Han Chinese | 24 |
| rs3138557/rs2430561 haplotype | Number of vessels affected and severity in coronary heart disease | Korean | 25 |
| rs2430561 (+874T/A) | Cortical cataracts and posterior subcapsular cataracts | Indian | 26 |
| rs2430561 (+874T/A) | Mild pulmonary tuberculosis | Pakistani | 27 |
| rs2430561/IL10 rs1800870/IL6 | |||
| rs1800795 haplotype | Tuberculosis (mild or advanced) | Pakistani | 27 |
| rs2430561 (+874T/A) | Aplastic anaemia | Chinese | 28 |
| rs2430561 (+874T/A) | Response to immunosuppressive therapy in aplastic anaemia | Chinese | 28 |
| rs2069727 (A/G) | Acute lymphoblastic leukaemia in males | Welsh and Mexican | 29 |
| rs2430561 (+874T/A) | Protective against leprosy | Brazilian | 30 |
| rs11177074 (C/T) | Cervical cancer | Costa Rican | 31 |
| rs2069727/rs2069718/rs2430561/rs2069705 haplotype | Atopic dermatitis complicated by eczema herpeticum | Mixed African American and Caucasian | 32 |
| rs2430561 (+874T/A) | Chagas disease | Colombian | 33 |
| rs2430561 (+874T/A) | Tuberculosis (pulmonary and extra-pulmonary) | Brazilian | 34 |
| rs2430561 (+874T/A) | Cervical cancer | Swedish | 35 |
| rs2069705 | Systemic lupus erythematosus | Korean | 36 |
| rs2430561 (+874T/A) | Mediterranean spotted fever | Sicilian | 37 |
| TNFA rs1800629/IL6 rs1800795/IFNG rs2430561 haplotype | Spontaneous preterm birth | Brazilian | 38 |
| rs2430561 (+874T/A) | Cervical cancer | Indian | 39 |
| rs2430561 (+874T/A) | Psoriasis vulgaris | Polish | 40 |
| rs2069707 (−764C/G) | Recovery from hepatitis C virus infection | American | 41 |
| rs3138557 (CA repeat) rs2430561(+874T/A) | Chronic hepatitis B virus infection | Polynesian | 42 |
| rs2430561(+874T/A) | Liver cirrhosis in chronic hepatitis C | Taiwanese | 43 |
| rs2430561(+874T/A) rs3138557 (CA repeat) | IgA nephropathy | Italian | 44 |
| rs2430561 (+874T/A) rs3138557 (CA repeat) rs2430561(+874T/A) | Intrauterine hepatitis B virus infection | Chinese | 20 |
| rs2430561(+874T/A) | Tuberculosis | Sicilian | 19 |
| −1616G/A | Pulmonary tuberculosis | West African | 18 |
| +3234T/C | Pulmonary tuberculosis | West African | 18 |
| rs2069709 (−179G/T) | AIDS progression in HIV-positive individuals | African American | 17 |
| +2109A/G | Severe hepatic fibrosis in hepatic schistosomiasis | Sudanese | 16 |
| +3810G/A | Severe hepatic fibrosis in hepatic schistosomiasis | Sudanese | 16 |
| rs2430561(+874T/A) | Tuberculosis | Chinese | 15 |
| rs3138557 (CA repeat) | Tuberculosis | Chinese | 15 |
| rs3138557 (CA repeat) | Hepatitis E | Indian | 45 |
| rs3138557 (CA repeat) | Tuberculosis | Chinese | 46 |
| rs2430561(+874T/A) | Tuberculosis | Chinese | 46 |