Table 4.
Interferon-γ epigenetic modification and disease
| Modification of interferon-γ gene | Association | References |
|---|---|---|
| Hypermethylation in effector T cells | Asthma (in discordant asthmatic twins) | 76 |
| Hypermethylation of the promoter in blood DNA | Diisocyanate induced occupational asthma | 71 |
| Hypomethylation | Increased diastolic blood pressure in elderly subjects | 72 |
| Hypomethylation of the promoter in T cells | Biliary atresia | 73 |
| Hypomethylation in bile duct cells | Biliary atresia | 74 |
| Hypomethylation of the promoter | Gingival biopsy samples of sites of chronic periodontitis | 77 |
| Hypomethylation | Samples of inflamed dental pulp, compared with healthy dental pulp | 78 |
| Hypomethylation in peripheral T cells | Inflammatory bowel disease patients requiring surgery, compared with non-surgical patients | 68 |
| Hypomethylation of the promoter in blood DNA | Increasing job seniority in chemical plant workers | 69 |
| Hypomethylation of the promoter | Severe acute graft-versus-host disease | 70 |