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. 2014 Nov 10;143(4):588–600. doi: 10.1111/imm.12337

Figure 1.

Figure 1

Stimulation of peripheral blood mononuclear cells (PBMC) with herpes simplex virus type 1 (HSV-1) induces natural killer (NK) cell activation. A total of 1 × 106 PBMC were exposed to CpG-A (ODN 6016), UV-inactivated and infectious HSV-1 (HSVUV and HSVINF), and interleukin-2 (IL-2). At 12 hr post stimulation, NK cell activation, cytokine secretion and degranulation were determined via CD69 expression, interferon-γ (IFN-γ)secretion, and CD107a surface expression, respectively. The percentages of NK cells expressing these markers are given as mean and standard error of 15 independent experiments. *P < 0·05, **P < 0·01 versus mock; #< 0·05, ##P < 0·01 HSVUV versus HSVINF (Tukey HSD). A representative FACS plot is shown on the right.