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. 2014 Nov 10;143(4):588–600. doi: 10.1111/imm.12337

Figure 4.

Figure 4

Plasmacytoid dendritic cells (pDC) and monocytes are major sources of tumour necrosis factor-α (TNF-α) upon exposure to herpes simplex virus type 1 (HSV-1). (a) Percentages of pDC, monocytes, B cells, natural killer (NK) cells, γδ T cells, CD4+ and CD8+ T cells secreting TNF-α at 18 hr post stimulation, analysed by flow cytometry for the individual cell populations. (b) Overall TNF-α secretion within peripheral blood mononuclear cells (PBMC), considering the frequency of each cell type within the PBMC population. Data represent mean and standard error of five independent experiments. *P < 0·05, **P < 0·01 versus mock; #P < 0·05, ##P < 0·01 HSVUV versus HSVINF (Tukey HSD). The figure legend applies to both figures.