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. 2014 Aug 8;33(20):2422–2435. doi: 10.15252/embj.201488299

Figure 2. Close-up view of DNA recognition by Mre11.

Figure 2

A Close-up view of MjMre11–DNA interaction. DNA-interacting residues from Mre11 A and Mre11 B are shown in cyan and pink, respectively. See also Supplementary Fig S3C and D for cartoon representations of the MjMre11–DNA1 and Mre11–DNA2 interfaces, respectively. Hydrogen bonds and ion-pairs are shown as dotted lines. An interaction between Ser131 (Mre11B) and the 5′ end of template strand is observed only in Mre11–DNA1.

B An orthogonal view of (A).

C Surface representation of the MjMre11 dimer bound to DNA1 (yellow and orange). Positively and negatively charged regions are shown in blue and red, respectively. A cluster of basic residues including Lys129, Lys130, and Lys132 on each Mre11 molecule is marked with a dashed circle.

D Close-up view of the PfMre11-synaptic DNA interaction (3DSC). The figure is drawn in the same orientation as that of (A).

E Close-up view of the PfMre11-branched DNA complex (3DSD).

F Structural comparison of DNA1 (yellow and orange) and B-form DNA (blue).