Table 2.

Reversal of MDS and Cytogenetic Abnormalities after HSCT

Donor	Patient	Pre Transplant Bone Marrow			Pre Transplant Treatment	2 years Post Transplant Bone Marrow
		Diagnosis	Cytogenetics	Cellularity**		Diagnosis	Cytogenetics	Cellularity**
MRD
	1	RCMD	Normal	Hypocellular	None	Trilineage hematopoiesis	46, XY	Normocellular
	2	RCMD	N/A	Hypocellular	None	ND	ND	ND
	3	RCMD	Trisomy 1q	Hypocellular Gr 1–2 Fibrosis	None	Trilineage hematopoiesis	46, XY	Hypocellular Gr 1 Fibrosis
	4	RCMD	Trisomy 8	Hypocellular Gr 1–2 Fibrosis	None	Trilineage hematopoiesis	46, XX	Hypocellular Gr 1–2 Fibrosis
URD
	5	RCMD	-Y	Hypocellular Gr 2 Fibrosis	None	*Trilineage hematopoiesis	46, XX	Normocellular Gr 2 Fibrosis
	6	RCMD	Trisomy 8	Hypocellular Gr 1–2 Fibrosis	None	Trilineage hematopoiesis	46. XX	Hypocellular Gr 1–2 Fibrosis
	7	RAEB1	Monosomy 7	Hypercellular	3+7	Trilineage hematopoiesis	46, XX	Normocellular Gr 1 Fibrosis
		RCMD	Trisomy 8	Hypocellular	None	ND	ND	ND
UC
	9	RAEB2	Monosomy 6, +r	Normocellular Gr 3 Fibrosis	3+7	Trilineage hematopoiesis	46, XY	Hypocellular Gr 3–4 Fibrosis
	10	RCMD	Monosomy 7	Hypocellular	None	Trilineage hematopoiesis	46, XY	Hypocellular
	11	RCMD	Monosomy 7, Trisomy 21	Hypocellular Gr 2 Fibrosis	None	ND	ND	ND
	12	RCMD	Monosomy 6	Hypocellular Gr 2 Fibrosis	None	ND	ND	ND
Haplo
	13	CMML	Monosomy −7q Trisomy 8	Hypercellular Gr 2 Fibrosis	HIDAC, Melphalan	ND	ND	ND
	14	HLH, EBV (+) T cell LPD	Normal	Hypocellular	Alemtuzumab,et oposide (HLH)	*Trilineage hematopoiesis, no EBV detected	N/A	Hypocellular

Abbreviations: RAEB: Refractory Anemia with Excess Blasts; LPD: lymphoproliferative disorder; N/A: not available; ND: Not done as patient died prior to 2 years.

^*Results of last available marrow. Patient 5 refused bone marrow biopsies as of 6 months post transplant. Patient 9 is only 9 months post transplant.

^**Cellularity for age (100% - age +/− 10%)