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Enhanced tumor response in BK5.EP4 mice. A two‐stage DMBA/TPA protocol was carried out with WT and lines 2 and 9 of the BK5.EP4 mice. A. Papilloma multiplicity (average number of tumors per mouse; n = 13 WT, n = 8 line 2, n = 12 line 9 BK5.EP4 mice). B. Cumulative squamous cell carcinomas (SCCs) in line 9 BK5.EP4 (n = 28) and WT (n = 30) mice. C. Histology of H&E stained sections from SCCs from WT, line 2 and line 9 BK5.EP4 mice.
