Table 2.

Demographics, concentration, and clearance data on study animals during fetal administration of fluoxetine

Animal	Estimated fetal weight at drug infusion (g)a	Gestational age at drug infusion (d)	Dose (mg/d)	Maternal plasma (ng/mL)		Fetal plasma (ng/mL)		Fetal clearance
				Fluoxetine	Norfluoxetine	Fluoxetine	Norfluoxetine	Fluoxetine (mL/min)	Normalized to fetal weight (mL/min/kg)
362	554	143	4.6	not detected	not detected	19.0 ± 1.00	not detected	168	303
367	660	149	1.83	not detected	not detected	7.0 ± 0.82	not detected	182	275
367	683	153	4.08	not done	not done	9.7 ± 5.77	not detected	293	429
372	371	141	5.3	not done	not done	17.2 ± 4.82	4.5 ± 0.71	642	1730
373	421	145	5.7	not done	not done	21.0 ± 3.65	not detected	188	448
394	518	137	15.4	4.7 ± 1.53	4.0	52.3 ± 15.9	5.3 ± 0.58	204	395
397	563	145	15.9	16.1 ± 1.95	29.6 ± 7.2	34.1 ± 13.5	10.3 ± 2.42	324b	575b
							Overallc	303 ± 177	594 ± 511

Where appropriate, data are given as mean ± 1 SD.

^aFetal weights were extrapolated from birth weight by using a trendline from present and prior time-mated baboon birth weights (n = 32). When birth weight was unavailable, mean birth weight for gestational age was used.

^bNorfluoxetine clearance, 450 mL/min; norfluoxetine clearance normalized to fetal weight, 800 mL/min/kg.

^cMeans for individual baboons were calculated before determining the overall mean across all animals.