A. All potential flank tumors were measured at 3 (Top) and
6 (Bottom) weeks post-implantation. Stromal:tumor (S:T) and tumor:tumor (T:T)
combinations were implanted on the left and right flanks, respectively.
B. Labels: Red, Orange, Green, Blue corresponds to
pre-treatment control, cyclopamine, RT and dual therapy groups. At 6 weeks
post-implantation, final measurements were taken and tumors harvested for
analysis. C. Representative excised tumors are shown for each of
the four pre-treatment arms with corresponding left and right flank tumors for
the two different groups.