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. 2014 Nov 25;14:99. doi: 10.1186/s12911-014-0099-1

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© Reibnegger and Schrabmair; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The dependence of the cut-off levels and the associated sensitivities and specificities on P(D) for a representative example. The results of the Monte-Carlo computations of scenario 1 with 200 fictitious “individuals” are shown in dependence on pre-test probability P(D). The left column (panels a1, a2 and a3) shows the mean values of cut-off levels and the associated sensitivities and specificities; the right column (panels b1, b2 and b3) visualizes the respective SD values. The colours of the lines symbolize the three methods for determining optimum cut-off levels: blue, Mutual information method; red, Youden index method; black, LR method.