Figure 2.

The HIV RNA+/ Ab- envelopes have greater sensitivity to CCR5 and fusion inhibitors. Scatter plots show IC₅₀s to CD4 antibody (A), Maraviroc (B), and Enfuvirtide (C) with a line denoting the median. Each individual symbol represents a subject’s mean from a minimum of 3 independent experiments. Circles denote the estimates for the HIV RNA+/Ab- subjects. The longitudinal sampling is denoted by a unique symbol (♦ A2, ■ A4, ○ A5, ★ A17, ▲ A18, ▼ A23, ●A27 ) for each subject. Symbols in gray denote virus stocks shown to be able to utilize the CXCR4 receptor. Significant differences (p ≤0.05) are indicated with a star in the graphs. Four envelope quasispecies with the documented ability to use the CXCR4 receptor were omitted from the examination of Maraviroc sensitivity.