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Metformin protects explants from gentamicin toxicity.
Gentamicin treatment (3.5 μM for 72 hours) damaged OHCs in a graded fashion with maximal damage to the base of the cochlea (n = 6). Metformin (15 μM for 72 hours) alone did not cause any OHC loss (n = 4) and protected hair cell integrity when co-administered with gentamicin (n = 4). Red: rhodamine phalloidin. Scale bar = 20 μm.
