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. Author manuscript; available in PMC: 2015 Nov 7.
Published in final edited form as: Neurosci Lett. 2014 Sep 18;583:65–69. doi: 10.1016/j.neulet.2014.09.028

Figure 4.

Figure 4

Metformin does not prevent gentamicin-induced loss of auditory function.

A: Gentamicin (100 mg/kg × 14 d) induced a significant threshold shift at 32 kHz which was not attenuated by co-administered metformin. M30, 30 mg/kg metformin (n=3); M100, 100 mg/kg metformin (n=3); G100, 100 mg/kg gentamicin (n=9); G+M30, 100 mg/kg gentamicin + 30 mg/kg metformin (n=3); G+M100, 100 mg/kg gentamicin + 100 mg/kg metformin (n=3).

B: Threshold shift induced by a lower dose of gentamicin (80 mg/kg × 14 d) was also not attenuated by co-administered metformin. M75, 75 mg/kg metformin (n=3); G80, 80 mg/kg gentamicin (n=9); G+M, 80 mg/kg gentamicin + 75 mg/kg metformin (n=3).

A and B. Animals were treated and ABR recorded as described in Methods. Data are means + SD. * threshold shifts of gentamicin-treated animals differ from metformin only treatment, p < 0.05, but there is no significant difference between the various gentamicin treatments in the absence or presence of metformin (One-way ANOVA followed by Student-Newman-Keuls multiple comparisons).