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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Pain. 2014 Sep 16;155(11):2390–2399. doi: 10.1016/j.pain.2014.09.009

Fig. 5. Three-way interaction between COMT, ESR1, and GCH1 SNPs on COMT activity and TMD risk.

Fig. 5

A. COMT enzyme activity (means ± s.e.m.) and B. TMD frequency is plotted for each genotype. The GCH1 rs10483639 C allele increases COMT activity and reduces TMD risk among met carriers, while the ESR1 rs3020377 G allele decreases COMT activity and increases TMD risk among val carriers with only 0 or 1 copy of the GCH1 rs10483639 C allele.