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. Author manuscript; available in PMC: 2015 Oct 31.
Published in final edited form as: Biochem Biophys Res Commun. 2014 Oct 6;453(4):722–727. doi: 10.1016/j.bbrc.2014.09.134

Figure 4.

Figure 4

(A) Interaction between surface-adsorbed Cp and free MPO was inhibited by pre-incubating MPO with anti-P18 antisera, excess free Cp, or ascorbate oxidase (AO) (mean ± SEM, n = 4 well per reaction, p<0.05). (B) MPO activity measured by incubating MPO with peroxidase substrate. Various concentrations Cp with or without anti-P18 antisera, and AO were preincubated with MPO to inhibit its peroxidase activity (mean ± SEM, n = 4 well per reaction, p<0.05). (C) Crystal structure of Cp with highlighted P18 and P76 sequences visualized by PyMOL. (D) A model for Cp-MPO interaction that results in MPO inhibition.