Table 1.
Collagens found in Periodontal Ligament
| Collagen | Form | Gene | Human disease |
Mechano-re sponse |
References |
|---|---|---|---|---|---|
| Type I | Fibrillar | COL1A1, COL1A2 | OI, EDS type VIIA and VIIB |
◯ | [38,138] |
| Type II | Fibrillar | COL2A1 | Chondrodysplasia, Osteoarthrosis |
◯ | [40] |
| Type III | Fibrillar | COL3A1 | EDS type IV | ◯ | [19,38,40] |
| Type IV | Basement membrane |
COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6 |
Alport syndrome | ND | [174] |
| Type V | Fibrillar | COL5A1, COL5A2, COL5A3, COL5A4 |
EDS type I and II | ◯ | [38,175] |
| Type VI | Beaded filament | COL6A1, COL6A2, COL6A3 |
Bethlem myopathy, Ullrich muscular dystrophy |
◯ | [38,175] |
| Type XII | FACIT (PG) |
COL12A1 | Unknown, Disruption of
PDL in KO mice |
◯ | [38,138] |
| Type XI | Fibrillar | COL11A1, COL11A2 | Chondrodysplasias Osteoarthrosis |
◯ | [40,41] |
| Type XIV | FACIT (PG) |
COL14A1 | Unknown | ND | [38] |
| Type XV (EST-base) |
Basement membrane (PG) |
COL15A1 | Unknown | ND | [41] |
| Type XVI (EST-base) |
FACIT | COL16A1 | Unknown | ND | [41] |
UN; Unknown
ND; Not determined
PG; Proteoglycan
FACIT; Fibril associated collagens with interrupted triple helices
EST-base; Detected only in EST-base analysis
EDS; Ehlers-Danlos syndrome
OI; Osteogenesis imperfecta