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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2014 Sep 17;20(12):2042–2048. doi: 10.1016/j.bbmt.2014.09.007

Table 1.

Clinical Characteristics (n=22)

Age Karyotype FLT3 NPM1 Disease
Status		 Conditioning
Regimen		 Donor
Type		 GVHD
ppx		 Outcome
54 Normal ITD Mutant Refractory1 CyTBI MUD Tac/Mtx Died (relapse)
20 Normal ITD WT Refractory1 BuCy MUD CsA Mtx Died (relapse)
54 +8 ITD Mutant Refractory2 CyTBI MRD Tac/Mtx Died (NRM)
62 t(1; 14) ITD Mutant CR2 BuFlu (RIC) MUD Tac/Mtx Alive (CR)
35 Normal ITD Mutant CR2 Flu/Mel/TBI dUCB Tac/Siro Alive (CR)
49 +6p, −21 ITD WT CR2 BuCy MUD Tac/Mtx Alive (CR)
21 Normal ITD Unknown CR1 BuCy MUD Tac/Mtx/ATG Alive (CR)
54 Normal ITD Mutant CR1 CyTBI MRD Tac/Mtx Alive (CR)
49 Normal ITD Mutant CR1 BuCy MUD Tac/Mtx/ATG Alive (CR)
42 Normal ITD Mutant CR1 CyTBI MUD Tac/Mtx Alive (CR)
62 Normal ITD Mutant CR1 BuFlu (RIC) MUD Tac/Siro/Mtx Alive (CR)
58 Normal ITD WT CR1 BuClo (RIC) MRD Tac/Mtx Alive (CR)
53 +8 ITD Unknown CR1 FluMel (RIC) MRD Tac/Mtx Alive (CR)
67 Normal ITD WT CR1 FluCyTBI (RIC) Haplo Cy/Tac/MMF Alive (CR)
59 Normal ITD Mutant CR1 BuClo (RIC) MRD Tac/Mtx Alive (CR)
34 Normal ITD WT CR1 BuCy MRD Tac/Mtx Alive (Relapsed)
40 Normal ITD Mutant CR1 BuCy MUD Tac/Mtx Alive (CR)
65 Unknown ITD Mutant CR1 BuClo (RIC) MUD Tac/Mtx Alive (CR)
54 Normal ITD WT CR1 BuCy MRD Tac/Mtx Alive (CR)
50 t(2;3) ITD WT CR1 BuCy MUD Tac/Mtx Alive (CR)
62 +11 ITD WT CR1 BuFlu (RIC) MMUD Tac/Mtx/ATG Alive (CR)
63 Normal ITD Mutant CR1 BuFlu (RIC) MRD Tac/Mtx Alive (CR)
1

Achieved < 5% bone marrow blasts with sorafenib prior to HSCT

2

In BM aplasia after reinduction chemotherapy

Abbreviations:

GVHD = graft-vs.-host disease; ppx = prophylaxis; Cy = cyclophosphamide; TBI = total body irradiation; MUD = matched unrelated donor; Tac = tacrolimus; Mtx = methotrexate; NPM1 = nucleophosmin 1; WT = wild-type; Bu = busulfan; CsA = cyclosporine; MRD = matched related donor; NRM = non-relapsed mortality; t = translocation; CR = complete remission; Flu = fludarabine; RIC = reduced intensity conditioning; Mel = melphalan; dUCB = double umbilical cord blood; Siro = sirolimus; ATG = anti-thymocyte globulin; Clo = clofarabine; Haplo = haploidentical; MMF = mycophenolate mofetil; MMUD = mismatched unrelated donor