Table 1.
Age | Karyotype | FLT3 | NPM1 | Disease Status |
Conditioning Regimen |
Donor Type |
GVHD ppx |
Outcome |
---|---|---|---|---|---|---|---|---|
54 | Normal | ITD | Mutant | Refractory1 | CyTBI | MUD | Tac/Mtx | Died (relapse) |
20 | Normal | ITD | WT | Refractory1 | BuCy | MUD | CsA Mtx | Died (relapse) |
54 | +8 | ITD | Mutant | Refractory2 | CyTBI | MRD | Tac/Mtx | Died (NRM) |
62 | t(1; 14) | ITD | Mutant | CR2 | BuFlu (RIC) | MUD | Tac/Mtx | Alive (CR) |
35 | Normal | ITD | Mutant | CR2 | Flu/Mel/TBI | dUCB | Tac/Siro | Alive (CR) |
49 | +6p, −21 | ITD | WT | CR2 | BuCy | MUD | Tac/Mtx | Alive (CR) |
21 | Normal | ITD | Unknown | CR1 | BuCy | MUD | Tac/Mtx/ATG | Alive (CR) |
54 | Normal | ITD | Mutant | CR1 | CyTBI | MRD | Tac/Mtx | Alive (CR) |
49 | Normal | ITD | Mutant | CR1 | BuCy | MUD | Tac/Mtx/ATG | Alive (CR) |
42 | Normal | ITD | Mutant | CR1 | CyTBI | MUD | Tac/Mtx | Alive (CR) |
62 | Normal | ITD | Mutant | CR1 | BuFlu (RIC) | MUD | Tac/Siro/Mtx | Alive (CR) |
58 | Normal | ITD | WT | CR1 | BuClo (RIC) | MRD | Tac/Mtx | Alive (CR) |
53 | +8 | ITD | Unknown | CR1 | FluMel (RIC) | MRD | Tac/Mtx | Alive (CR) |
67 | Normal | ITD | WT | CR1 | FluCyTBI (RIC) | Haplo | Cy/Tac/MMF | Alive (CR) |
59 | Normal | ITD | Mutant | CR1 | BuClo (RIC) | MRD | Tac/Mtx | Alive (CR) |
34 | Normal | ITD | WT | CR1 | BuCy | MRD | Tac/Mtx | Alive (Relapsed) |
40 | Normal | ITD | Mutant | CR1 | BuCy | MUD | Tac/Mtx | Alive (CR) |
65 | Unknown | ITD | Mutant | CR1 | BuClo (RIC) | MUD | Tac/Mtx | Alive (CR) |
54 | Normal | ITD | WT | CR1 | BuCy | MRD | Tac/Mtx | Alive (CR) |
50 | t(2;3) | ITD | WT | CR1 | BuCy | MUD | Tac/Mtx | Alive (CR) |
62 | +11 | ITD | WT | CR1 | BuFlu (RIC) | MMUD | Tac/Mtx/ATG | Alive (CR) |
63 | Normal | ITD | Mutant | CR1 | BuFlu (RIC) | MRD | Tac/Mtx | Alive (CR) |
Achieved < 5% bone marrow blasts with sorafenib prior to HSCT
In BM aplasia after reinduction chemotherapy
Abbreviations:
GVHD = graft-vs.-host disease; ppx = prophylaxis; Cy = cyclophosphamide; TBI = total body irradiation; MUD = matched unrelated donor; Tac = tacrolimus; Mtx = methotrexate; NPM1 = nucleophosmin 1; WT = wild-type; Bu = busulfan; CsA = cyclosporine; MRD = matched related donor; NRM = non-relapsed mortality; t = translocation; CR = complete remission; Flu = fludarabine; RIC = reduced intensity conditioning; Mel = melphalan; dUCB = double umbilical cord blood; Siro = sirolimus; ATG = anti-thymocyte globulin; Clo = clofarabine; Haplo = haploidentical; MMF = mycophenolate mofetil; MMUD = mismatched unrelated donor