Table 2.
Formulation of gastroretentive floating tablet.
| Batch code | Coded level | Pluronic F127 (mg) | Polyox WSR 205 (mg) | Sodium bicarbonate (mg) | Citric acid (mg) | Magnesium stearate (mg) | Talc (mg) | Di calcium phosphate (mg) | |
|---|---|---|---|---|---|---|---|---|---|
| Variable 1 (Pluronic F127) | Variable 2 (Polyox WSR 205) | ||||||||
| F1 | − | − | 25.2 | 135 | 58 | 10 | 1 | 1 | 36 |
| F2 | − | 0 | 25.2 | 145 | 58 | 10 | 1 | 1 | 26 |
| F3 | − | + | 25.2 | 153 | 58 | 10 | 1 | 1 | 18 |
| F4 | 0 | − | 35 | 135 | 58 | 10 | 1 | 1 | 26 |
| F5 | 0 | 0 | 35 | 145 | 58 | 10 | 1 | 1 | 16 |
| F6 | 0 | + | 35 | 153 | 58 | 10 | 1 | 1 | 8 |
| F7 | + | − | 43.2 | 135 | 58 | 10 | 1 | 1 | 18 |
| F8 | + | 0 | 43.2 | 145 | 58 | 10 | 1 | 1 | 8 |
| F9 | + | + | 43.2 | 153 | 58 | 10 | 1 | 1 | 0 |
Weight is expressed as mg per tablet. Total weight of tablet was 370 mg.